OpusJournal

Online ISSN:
2831-090X

ISSN:
2831-0896

Volume 23 , Issue 2, (2023)

Published:
11.07.2023.

Open Access

Vol.23 No.2

Published: 11.07.2023.

Authors in this issue:

Abdella M Habib, Abdul-Badi Abou-Samra, Aleksandra Aracki Trenkić, Angela Pia Cazzolla, Atalla Hammouda, Benjie Xu, Boris Zec, Cheng Rao, Chenwei Li, Chunyue Feng, Dan Li, Dejan Nesic, Domenico Ciavarella, Dominik Vilímek, Dragan Stojanov, Eleonora Lo Muzio, Elina Beleva, Fang Li, Fei Liu, Feng Wang, Francesca Di Serio, Francesca Spirito, Gaofei Cao, Gordana Petrovic, Haibo Lu, Hao Jiang, Haowen Pang, Hongbing Ma, Hua Yang, Ivanka Nenova, Jan Malůš, Jaroslav Uchytil, Jianguang Shi, Jiayue Shao, Jie Gong, Jie Lian, Jieqiu Zhang, Jieyun Huang, Jin Li, Jun Wang, Justin Clark, Kai Sun, Lichun Wei, Lina Zhao, Ling-Yu Long, Lishuang Wang, Liu Shi, Lorenzo Lo Muzio, Lucia Varraso, Luigi Santacroce, Luka Nikolic, Marek Bužga, Maria Pepe, Mario Dioguardi, Matej Pekař, Mei Shi, Mengyao Zhang, Michele Di Cosola, Milica Radovanović, Milica Živanović, Miroslav Mišić, Mohan Dong, Moustapha Hamdi, Nan Xu, Omran A H Musa, Pavol Holéczy, Petr Kutáč, Qian Jiang, Qian Zhang, Qiong Qing, Quan-Bing Zhang, Ren Wang, Renato Contino, Roberto Lovero, Rui Zhang, Run Zhang, Saif Badran, Sanja Ninic, Sara Alharami, Sasa Popovic, Semir Vranic, Sergej Prijic, Shigao Huang, Shuli Tang, Siqi Liu, Snezana Ristic, Snezhana Stoencheva, Srdjan Pasic, Stasa Krasic, Suhail A Doi, Tanya Deneva, Veronika Horká, Vito Crincoli, Vladislav Vukomanovic, Vuk Milošević, Vukota Radovanović, Weijie Wu, Weiwei Li, Wen-Min Chen, Wudong Wang, Xiangyi Pang, Xiao-Jun Huang, Xiaopeng Yao, Xiaoxiao Liu, Xin Wang, Xinjian Li, Xu Wang, Xuejing Zhong, Ya-Zhen Qin, Yanhui Chen, Ying Zhang, Yingying Jin, Yongrong Zhang, Yuchen Wang, Yun Zhou, Zdeněk Švagera, Zhanet Grudeva-Popova, Zhenjing Jin, Zishan Wang,

Edited by:

Muzafer Mujic & Semir Vranic

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Possible mechanism of static progressive stretching combined with extracorporeal shock wave therapy in reducing knee joint contracture in rats based on MAPK/ERK pathway

The study aimed to observe the therapeutic effect of static progressive stretching (SPS) combined with extracorporeal shock wave therapy (ESWT) on extension knee joint contracture in rats and the effect on the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway in the development of joint capsule fibrosis. Thirty-six Sprague Dawley rats were randomly divided into blank control group, immobilization model group, natural recovery group, ESWT intervention group, SPS intervention group, and SPS combined with ESWT intervention group. The left knee joints of the rats, except for the control group, were fixed with an external fixation brace for four weeks at full extension to form joint contracture. The therapeutic effect of each intervention was assessed by evaluating total and arthrogenic contracture, the number of total cells and collagen deposition in the anterior joint capsule, the protein levels of TGF-β1, FGF-2, and ERK2 in the anterior joint capsule, the mean optical density of upstream RAS and downstream ERK2 positive expression in the MAPK/ERK pathway. SPS in combination with ESWT was more effective in relieving joint contracture, improving the histopathological changes in the anterior joint capsule, and suppressing the high expression of target proteins and the overactivated MAPK/ERK pathway. The overactivated MAPK/ERK pathway was involved in the formation of extension knee joint contracture in rats. SPS in combination with ESWT was effective in relieving joint contracture and fibrosis of joint capsule. Moreover, the inhibition of the overactivated MAPK/ERK pathway may be the potential molecular mechanism for its therapeutic effect.

Run Zhang, Quan-Bing Zhang, Yun Zhou, Rui Zhang, Feng Wang